'That oxygen-derived free radicals are implicated in the pathogenesis of shock is now well accepted. These potentially toxic by-products of normal cellular metabolism - superoxide, hydroxyl radical, hydrogen peroxide - are, in healthy tissue, removed by endogenous scavengers. However, in disease states, the extent of free radical production may increase, and the activity of natural scavenging mechanisms may be reduced; free radical activity then represents and important component in the complex process of tissue injury. This volume comprises the proceedings of a workshop, organised by the Euro0pean Shock Society, in which experts in biochemistry, pathology, physiology, pharmacology, anaesthesiology, intensive care, surgery and cardiology convened to discuss their latest findings on the role of oxygen free radicals in shock.'
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