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The Future of Predictive Safety Evaluation volume 2

£80.00

Product description

Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten- tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi- tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com- pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.

slight shelf wear and small marks to cover, otherwise very good condition.

Item details

Author(s):
Worden, A; Parke, D; Marks, J (editors)
Condition:
Used: very good
ISBN-10:
0852006942
ISBN-13:
9780852006948
Publisher:
MTP
Title:
The Future of Predictive Safety Evaluation volume 2

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About this item

Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten- tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi- tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com- pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.

slight shelf wear and small marks to cover, otherwise very good condition.

Author(s):
Worden, A; Parke, D; Marks, J (editors)
Condition:
Used: very good
ISBN-10:
0852006942
ISBN-13:
9780852006948
Publisher:
MTP
Title:
The Future of Predictive Safety Evaluation volume 2

Delivery & returns

This item will be dispatched to UK addresses via second class post within 2 working days of receipt of your order. Standard UK delivery is £3.95 per order, so you're only charged once no matter how many items you have in your basket. Any additional courier charges will be applied at checkout as they vary depending on delivery address.

This item will be dispatched to UK addresses via second class post within 2 working days of receipt of your order. Standard UK delivery is currently free, no matter how many items you have in your basket. Any additional courier charges will be applied at checkout as they vary depending on delivery address.

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Europe: £14.00

Outside Europe: £28.00

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