Oxfam is sending humanitarian experts to Morelos and Puebla, two of the areas worst affected by Tuesday's 7.1 earthquake that struck central Mexico.
Over 200 people have died and hundreds are injured. Many remain trapped under the rubble.
Oxfam's response is likely to focus on providing food, water and sanitation, and making sure people are safe.
Ricardo Fuentes-Nieva, Executive Director of Oxfam Mexico, said:
"Morelos and Puebla are poorer states neighbouring Mexico City and close to the epicentre of the earthquake. Many people here have lost everything. Oxfam is ready to do whatever is needed to ensure that people have access to clean water and sanitation.
"The most marginalised communities which are often forgotten, must be a priority."
This is the second earthquake to strike Mexico in less than two weeks.
Oxfam spokespeople are available in Mexico, who can speak Spanish and English. Please contact Sarah Dransfield on +44 (0)7884 114825 or Tania Escamilla email@example.com / +52 (1) 55 4890 8019