"The authors represent most of the key figures and the work andthe book as a whole is an essential reference for the newcomer orspecialist in this area and for any student of eukaryotic cellstructure and function. This is an important and wonderfulreference." -Microbiology Today, May 2009 Septins are an evolutionarily conserved group of GTP-binding andfilament-forming proteins that were originally discovered in yeast.Once the preserve of a small band of yeast biologists, the fieldhas grown rapidly in the past few years and now encompasses thewhole of animal and fungal biology. Furthermore, septins arenowadays recognized to be involved in a variety of diseaseprocesses from neoplasia to neurodegenerative conditions.This book comprehensively examines the septingene family and their proteins, providing those new to thisresearch area with a detailed and wide ranging introduction toseptin biology. It starts with a unique historical perspective onthe development of the field, from its beginnings in the screen forcell division mutants by the Nobel Laureate Lee Hartwell. Theevolution of the septin gene family then forms a basis forconsideration of the biochemistry and functions of septins in yeastand other model organisms including C. elegans andDrosophila. A major part of the book considers the diversity of septins inmammals, their functions and properties as well as theirinvolvement in normal and abnormal cellular states, followed by aspeculative overview from the editors of the key questions inseptin research and of where the field may be headed.In addition, several appendices summarise important informationfor those in, or just entering, the field, e.g. nomenclature andseptin and septin-like sequences.This book is an essential source of reference materialfor researchers in septin biology, cell biology, genetics andmedicine, in particular pathology, including areas of neurobiology,oncology, infectious disease and developmental biology.
Overall in new condition, still in plastic wrapping.